Which statement about the two most common syndromes identified by MyRisk is true?

Which statement about the two most common syndromes identified by MyRisk is true?

• A. They are not related to breast cancer risk
• B. They are identified only in male patients
• C. HBOC and Lynch syndrome are the two most common syndromes identified by MyRisk
• D. They require genetic testing to confirm

Answer: (C)

The main idea here is understanding what MyRisk most often flags in people with a hereditary cancer risk history. MyRisk is a risk assessment tool that analyzes personal and family cancer history to highlight possible hereditary cancer syndromes. The two syndromes it most commonly identifies are hereditary breast and ovarian cancer (HBOC) syndrome and Lynch syndrome. HBOC is linked to BRCA1/2 (and other related genes) and raises risk for breast and ovarian cancer (and others), while Lynch syndrome is due to defects in mismatch repair genes and markedly increases risk for colorectal and endometrial cancers, among others. Because these two syndromes are the most frequently flagged in risk assessments like MyRisk, they’re the correct pairing. The other statements don’t fit: HBOC is indeed related to breast cancer risk, not unrelated; both sexes can be identified and carry these syndromes, not only males; and while genetic testing is used to confirm specific pathogenic variants after a risk assessment, the claim about the two most common syndromes identified by MyRisk is about which syndromes appear most often rather than the necessity of testing to confirm.

The main idea here is understanding what MyRisk most often flags in people with a hereditary cancer risk history. MyRisk is a risk assessment tool that analyzes personal and family cancer history to highlight possible hereditary cancer syndromes. The two syndromes it most commonly identifies are hereditary breast and ovarian cancer (HBOC) syndrome and Lynch syndrome. HBOC is linked to BRCA1/2 (and other related genes) and raises risk for breast and ovarian cancer (and others), while Lynch syndrome is due to defects in mismatch repair genes and markedly increases risk for colorectal and endometrial cancers, among others. Because these two syndromes are the most frequently flagged in risk assessments like MyRisk, they’re the correct pairing. The other statements don’t fit: HBOC is indeed related to breast cancer risk, not unrelated; both sexes can be identified and carry these syndromes, not only males; and while genetic testing is used to confirm specific pathogenic variants after a risk assessment, the claim about the two most common syndromes identified by MyRisk is about which syndromes appear most often rather than the necessity of testing to confirm.