Which Myriad test determines HRD status?

Which Myriad test determines HRD status?

• A. BRACAnalysis
• B. MyChoice CDx
• C. OncoVantage
• D. HRDSense

Answer: (B)

HRD status reflects a tumor’s deficiency in homologous recombination repair, which makes it more likely to respond to PARP inhibitors. The test designed to determine this status is MyChoice CDx, as it specifically assesses tumor genomic instability to produce an HRD score (beyond just BRCA gene status) and is used as a companion diagnostic to guide PARP inhibitor therapy. The BRACAnalysis test looks for inherited BRCA1/2 mutations and does not measure tumor HRD. The other tests mentioned are not the standard HRD-determining assay in clinical use. So, the test that determines HRD status is MyChoice CDx.

HRD status reflects a tumor’s deficiency in homologous recombination repair, which makes it more likely to respond to PARP inhibitors. The test designed to determine this status is MyChoice CDx, as it specifically assesses tumor genomic instability to produce an HRD score (beyond just BRCA gene status) and is used as a companion diagnostic to guide PARP inhibitor therapy. The BRACAnalysis test looks for inherited BRCA1/2 mutations and does not measure tumor HRD. The other tests mentioned are not the standard HRD-determining assay in clinical use. So, the test that determines HRD status is MyChoice CDx.