Which model is also called IBIS?

Which model is also called IBIS?

• A. Gail model
• B. BRCAPRO
• C. Tyrer-Cuzick
• D. BOADICEA

Answer: (C)

The model known as IBIS is the Tyrer-Cuzick model. It’s implemented in the IBIS software (often used for breast cancer risk evaluation) and was developed to give individualized risk estimates by integrating a wide range of factors: personal factors like age and reproductive history, family history, and, when available, BRCA1/BRCA2 mutation status. This approach allows calculation of both short-term (5-year) and lifetime risk, aiding decisions about screening and prevention. Other models serve different purposes or use different data emphases—Gail focuses more on non-genetic factors in a general population, BRCAPRO centers on estimating BRCA mutation likelihood from family history, and BOADICEA uses detailed pedigree data and polygenic risk. Because the IBIS/ Tyrer-Cuzick framework specifically underpins the IBIS risk tool, it is the one associated with that name.

The model known as IBIS is the Tyrer-Cuzick model. It’s implemented in the IBIS software (often used for breast cancer risk evaluation) and was developed to give individualized risk estimates by integrating a wide range of factors: personal factors like age and reproductive history, family history, and, when available, BRCA1/BRCA2 mutation status. This approach allows calculation of both short-term (5-year) and lifetime risk, aiding decisions about screening and prevention. Other models serve different purposes or use different data emphases—Gail focuses more on non-genetic factors in a general population, BRCAPRO centers on estimating BRCA mutation likelihood from family history, and BOADICEA uses detailed pedigree data and polygenic risk. Because the IBIS/ Tyrer-Cuzick framework specifically underpins the IBIS risk tool, it is the one associated with that name.