What does RiskScore add to Tyrer-Cuzick?

What does RiskScore add to Tyrer-Cuzick?

• A. Polygenic risk (SNPs)
• B. Imaging data
• C. Lifestyle factors
• D. Family history only

Answer: (A)

It adds polygenic risk information from a large set of SNPs to the Tyrer-Cuzick model. Tyrer-Cuzick already uses traditional factors like age, family history, and reproductive factors to estimate risk. Incorporating a polygenic risk score captures inherited risk from many common genetic variants that each have small effects but together shift the overall risk, leading to a more individualized assessment. Imaging data are not part of this addition, and while lifestyle factors can be relevant in risk models, they are not what RiskScore contributes here. Family history is included in Tyrer-Cuzick, but the polygenic score adds information beyond what family history alone can explain.

It adds polygenic risk information from a large set of SNPs to the Tyrer-Cuzick model. Tyrer-Cuzick already uses traditional factors like age, family history, and reproductive factors to estimate risk. Incorporating a polygenic risk score captures inherited risk from many common genetic variants that each have small effects but together shift the overall risk, leading to a more individualized assessment. Imaging data are not part of this addition, and while lifestyle factors can be relevant in risk models, they are not what RiskScore contributes here. Family history is included in Tyrer-Cuzick, but the polygenic score adds information beyond what family history alone can explain.