How many tumor-specific variants can Precise MRD track?

How many tumor-specific variants can Precise MRD track?

• A. Up to 100 variants
• B. Up to 500 variants
• C. Up to 1,000 variants
• D. Up to 5,000 variants

Answer: (C)

Precise MRD tracks tumor-specific variants in circulating tumor DNA to detect residual cancer after treatment. By monitoring a set of variants unique to the patient's tumor, the assay looks for even tiny amounts of cancer DNA among normal DNA, boosting sensitivity. The system is designed to monitor up to about 1,000 variants per patient, which provides robust evidence of residual disease while keeping sequencing depth and DNA input practical. Tracking many variants helps account for tumor heterogeneity and subclonal evolution, reducing the chance of missing residual disease if some clones aren’t represented by a smaller panel. Too few variants could miss remaining cancer cells, while too many would require more DNA and deeper sequencing than is usually feasible, and could introduce more noise. So, the capacity that best fits these constraints is up to 1,000 variants.

Precise MRD tracks tumor-specific variants in circulating tumor DNA to detect residual cancer after treatment. By monitoring a set of variants unique to the patient's tumor, the assay looks for even tiny amounts of cancer DNA among normal DNA, boosting sensitivity. The system is designed to monitor up to about 1,000 variants per patient, which provides robust evidence of residual disease while keeping sequencing depth and DNA input practical. Tracking many variants helps account for tumor heterogeneity and subclonal evolution, reducing the chance of missing residual disease if some clones aren’t represented by a smaller panel. Too few variants could miss remaining cancer cells, while too many would require more DNA and deeper sequencing than is usually feasible, and could introduce more noise. So, the capacity that best fits these constraints is up to 1,000 variants.